![]() About 790 patients were included in the two chemotherapy-containing arms presented. The nivolumab plus ipilimumab arm was stopped early for undisclosed reasons. 9 Patients were randomly assigned to receive nivolumab plus chemotherapy (either FOLFOX or CAPOX), chemotherapy alone, or nivolumab plus ipilimumab. View largerĬheckMate-649 was a global, randomized phase III trial that included patients with untreated advanced adenocarcinoma of the esophagus, gastroesophageal junction (GEJ), or stomach, regardless of PD-L1 expression. The Figure below illustrates the evolution of immunotherapy in gastro-esophageal cancer in terms of lines of therapy and regulatory approvals. This year, however, the field has taken a giant step forward with the presentation of three randomized trials-CheckMate-649, ATTRACTION-4, and KEYNOTE-590-during the European Society for Medical Oncology Virtual Congress 2020 on September 21. ![]() 6,7 The KEYNOTE-062 trial failed to demonstrate superior overall survival (OS) with pembrolizumab compared with chemotherapy, and failed to show an additional benefit of pembrolizumab combined with chemotherapy compared with chemotherapy alone in first-line metastatic gastric cancer. 4,5 Nivolumab and pembrolizumab subsequently received FDA approval in the second-line setting (ATTRACTION-3 and KEYNOTE-181 trials, respectively), but only for esophageal squamous cell carcinoma (ESCC) and-for pembrolizumab-only for patients with tumor PD-L1 combined positive score (CPS) ≥ 10%. ![]() 3 The JAVELIN Gastric 100 and JAVELIN Gastric 300 studies compared avelumab to chemotherapy as first-line maintenance and second-line therapy, respectively, and also failed to demonstrate clinical benefit. The KEYNOTE-061 trial showed that pembrolizumab was not superior to chemotherapy in the second-line setting. 1,2 However, subsequent trial results were discouraging. Food and Drug Administration (FDA) approval and nivolumab was approved in Japan in the third-line metastatic setting (KEYNOTE-059 and ATTRACTION-2 trials, respectively), it appeared that immunotherapy would race forward into the first-line and adjuvant therapy settings. Three years ago, when pembrolizumab received U.S.
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![]() ![]() Requirements for design, operation and maintenance (British Standard) Lubrication of the gearbox is covered along with prototype and production testing.īS EN 50308:2004 Wind turbines. Guidance is included on the specification of shafts, shaft interfaces and fits, bearings and gear housing structure. Plain bearings are permissible, although their use and rating is not covered. The standard applies to designs using rolling element bearings. The gearing elements referenced include spur, helical or double helical and their combinations in parallel and epicyclic arrangements in the main power path. Furthermore, this method provides a means to evaluate designs based upon gearbox lifetime economics. A standardized method for calculating gearbox reliability is included which allows for an objective comparison of different gearbox designs. The standard provides guidance on the application of the wind turbine loads in relationship to the design of gears and gearbox elements. This standard applies to modular and integrated designs. This applies to wind turbines installed both onshore and offshore. SCOPE This standard is applicable to enclosed speed increasing gearboxes for horizontal axis wind turbine drivetrains with a power rating in excess of 500 kW. Annex information is supplied on wind turbine architecture, wind turbine load description, quality assurance, operation and maintenance, minimum purchaser gearbox manufacturer ordering data, lubrication selection and monitoring, determination of an application factor from a load spectrum using the equivalent torque, and bearing stress calculations. It provides information for specifying, selecting, designing, manufacturing, testing, procuring, operating and maintaining reliable speed increasing gearboxes for wind turbine generator system service. This standard is intended to apply to wind turbine gearboxes. Even if electrical overhead lines are covered by IEC standards, designers can use this document for the mast structures to overhead lines (which are not covered by IEC standards) if they so wish.ĪNSI/AGMA 6006-B20 Standard for Design and Specifications of Gearboxes for Wind Turbines Also, in many cases, only parts of structures are to be designed for ice loads because they are more vulnerable to unforeseen ice than is the whole structure. NOTE Some typical types of structure are mentioned, but other types can also be considered by designers by thinking in terms of which type of structure is sensitive to unforeseen ice, and act thereafter. This document is intended to be used in conjunction with ISO 2394. Atmospheric icing on electrical overhead lines is covered by IEC (International Electrotechnical Commission) standards. rope ways (cable railways) - structures for ski-lifts - buildings or parts of them exposed to potential icing - towers for special types of construction such as transmission lines, wind turbines, etc. ISO 12494:2017 is intended for use in determining ice mass and wind load on the iced structure for the following types of structure: - masts - towers - antennas and antenna structures - cables, stays, guy ropes, etc. In particular, the action of wind can be increased considerably due to both increased exposed area and increased drag coefficient. CAUTION It is extremely important to design for some ice instead of no ice, and then the question of whether the amount of ice was correct is of less importance. Using such an estimate in the structural design will result in a much safer structure than designing without any considerations for problems due to ice. Even in such cases, this document can be useful because local meteorologists or other experienced persons should be able to, on the safe side, estimate a proper ice class. For many areas, however, no information is available. ![]() Information about the degree of normal icing amounts (= ice classes) for the site in question is used. The practical use of all data in this document is based upon certain knowledge of the site of the structure. However, it is the user's responsibility to carefully consider the applicability of this document to the structure in question. In cases where a certain structure is not directly covered by this or another standard or recommendation, designers can use the intentions of this document. ![]() ISO 12494:2017 describes the general principles of determining ice load on structures of the types listed in this clause. ISO 12494:2017 Atmospheric icing of structures ![]() On October 31, Bush nominated Third Circuit Judge Samuel Alito to replace O'Connor, Alito was confirmed and sworn in on January 31, 2006. After retiring, she continued to hear cases and rendered over a dozen opinions in federal appellate courts across the country, filling in as a substitute judge when vacations or vacancies left their three-member panels understaffed.President Obama should appoint a replacement for late Supreme Court Justice Antonin Scalia because the Court needs “somebody in there to do the job and just get on with it,” retired Justice Sandra Day O’Connor told a TV station in her home state of Arizona. Two days later, Bush withdrew Roberts as his nominee for her seat and instead appointed him to fill the vacant office of Chief Justice. O'Connor agreed to stay on the Court until her replacement was named and confirmed. Circuit Judge John Roberts to succeed O'Connor. However, Rehnquist died on September 3, creating an immediate vacancy on the Court. In her letter to Bush, she stated that her retirement from active service would take effect upon the confirmation of her successor. On July 1, 2005, O'Connor announced her intention to retire. ![]() Later on, as the Court's make-up became more conservative, O'Connor often became the swing vote on the Court. Initially, O'Connor's voting record aligned closely with the conservative William Rehnquist and in nine of her first sixteen years on the Court, O'Connor voted with Rehnquist more than with any other justice. On September 21, O'Connor was confirmed by the U.S. Reagan formally nominated O'Connor on August 19, 1981, and her confirmation hearing before the Senate Judiciary Committee began on September 9, 1981. O'Connor received notification from President Reagan of her nomination on the day prior to the announcement and did not know that she was a finalist for the position. On July 7, 1981, Reagan announced he would nominate O'Connor as an Associate Justice of the Supreme Court to replace the retiring Potter Stewart. ![]() President Regan had pledged during his 1980 presidential campaign to appoint the first woman to the Court. She served on the Court of Appeals-Division One until 1981 when she was appointed to the Supreme Court by President Ronald Reagan. In 1974, O'Connor was elected to the Maricopa County Superior Court serving from 1975 to 1979 when she was elevated to the Arizona State Court of Appeals. After serving two full terms, O'Connor decided to leave the Senate. By 1973, she became the first woman to serve as Arizona's or any state's Majority Leader. She developed a reputation as a skilled negotiator and a moderate. In 1969, the governor of Arizona appointed O'Connor to fill a vacancy in the Arizona Senate. She ran for and won the election for the seat the following year. O'Connor served as assistant Attorney General of Arizona from 1965 to 1969. Following Brian's birth, O'Connor took a five-year hiatus from the practice of law. They had three sons: Scott (born 1958), Brian (born 1960), and Jay (born 1962). They remained there for three years before returning to the states where they settled in Maricopa County, Arizona, to begin their family. When her husband was drafted, O'Connor decided to pick up and go with him to work in Germany as a civilian attorney for the Army's Quartermaster Corps. She worked with San Mateo County district attorney Louis Dematteis and deputy district attorney Keith Sorensen. O'Connor then found employment as a deputy county attorney in San Mateo, California, after she offered to work for no salary and without an office, sharing space with a secretary. Upon graduation from law school, O'Connor had difficulty finding a paying job as an attorney because of her gender. On Decem(six months after graduating from law school), she married John Jay O'Connor III, whom she had met at Stanford Law School. Sandra Day attended Stanford University, where she graduated magna cum laude with a B.A. in economics in 1950. She continued at the Stanford Law School for her law degree in 1952. O'Connor spent her eighth-grade year living at the ranch and riding a bus 32 miles to school. She graduated sixth in her class at Austin High School in El Paso in 1946. The family cattle ranch was too far from schools, although O'Connor was able to return to the ranch for holidays and the summer. For most of her early schooling, O'Connor lived in El Paso with her maternal grandmother, and attended school at the Radford School for Girls, a private school. She grew up on a 198,000-acre cattle ranch near Duncan, Arizona. The ranch was nine miles from the nearest paved road. The family home did not have running water or electricity until Sandra was seven years old. Sandra Day was born in El Paso, Texas on March 26, 1930, the daughter of Harry Alfred Day, a rancher, and Ada Mae. ![]() ![]() World 5:Magma Crater is the Final World of the game.It is connected to the Glacier Ridge by it's Sloped Edge.It is a Volcanic World taking place in the Crater of a Volcano.It has the last 6 Stages(Stage 5-1 to 5-6),has the Final Miniboss and Major Boss.The Miniboss is a Large Lava Beetle. World 4:Glacier Ridge is the fourth World of the game.It is connected to the Rainforest's Boss Stage by a Large Entrance Gate made of Stone.It has 6 Levels with 1 Major Boss Stage and 1 Miniboss Stage.It is a Snowy Glacier at the Ridge of the Island.The Miniboss is a Large Glacier Anaconda(Probably Grandma Simbi?)and the Major boss is Garm(The Leader of Hell Hound Loomis) World 3:Wild Marsh is the third World of the game.A Long Ladder starting from an Edge of The Jungle connects to the Rainforest/Stage 3-1.It is a Wild Rainforest themed World with Dark Grass and Dark Trees.It has 6 stages(Stages 3-1 to 3-6) and has 1 Major Boss.The Major Boss here is Puff No More(Tentati ve) World 2:Castaway Jungle is the second World of the game.It can be entered by climbing a Ladder connecting the Beach/Stage 1-5 to the edge of the Jungle/Stage 2-1.It is Tropical Jungle themed, it has 6 stages(Stages 2-1 to 2-6) and is one of the Three Worlds with a Miniboss Stage.In this case,it is Stage 2-3.Like other Worlds,it has 1 Major Boss Stage.The Miniboss here resembles Peeping Tom and the Major Boss is similar to Sister Pedro.(Both are Tentative) World 1:Castaway Beach is the first World and Starting point of the game.It has a Beach Themed(As the named Implies) environment with 6 Levels(Stages 1-1 to 1-6) and has 1 Boss Level.The boss here is a Huge Sand Beetle. Discover and raise loyal pets that will fight by your side in this unique action RPG. Become a powerful warrior - growing your powers and abilities through over 50 quests across a distinct and visually stylized world. Stranded on a mysterious island, it is up to you to restore peace to its villagers. These 5 Worlds are actually the worlds (except Grasslands) in Castaway 1. Castaway, a free online Strategy game brought to you by Armor Games. ly/ISARTDigitalyoutubeShort filmGraduation Project. There are 5 Environments and 30 Levels (6 levels per World * 5 worlds = 30 Total Levels) in the game. The game, like many classic point-and-click adventure games, is viewed from a third-person perspective and is mouse-driven, with the player clicking on locations for the main character to move to and objects to examine or pick up, among other actions. Agarthas Castaway - Book 7 Sci-fi Fantasy by Chrissy Peebles. There are 30 Stages/Maps and 8 Boss Fights (5 Major Bosses and 3 Mini-Bosses) to clear. After you select your pet the Stage 1-1/ Room 1 will start. Now you can choose one of the 3 pets to accompany you on your Adventure. You arrive in the Castaway Beach (World 1) and Sigil gives a new goal for you: To Protect the Castaway Crystal. Travel an island with 30 levels spread across 5 unique environments. Control the hero from the Castaway series, as he builds towers to defend his island against waves of enemies. This Castaway spin-off combines real-time adventure with the strategy of tower defense games to create a new hybrid genre. ![]() Some tech comm tools allow you to do this, but even the ones that do tend to specialise in one over the others. If you are documenting software (as I have been for the last few years), is the documentation going to be printed, is it to be integrated into the package (in the form of a CHM file) or will it be online? If it’s going to be printed, will there be a PDF and will that be available to download? Whatever the case, you may have to deliver documentation to multiple endpoints. If you are documenting a piece of hardware, your primary endpoint will most likely be print media (to be packaged with the physical product). So, specialist technical communication tools are the way to go, but which ones, there’s so many? That is not easy to answer, not least because it depends on what you are documenting and how your documentation is going to be delivered. Technical communication needs to be flexible, extensible, re-usable and increasingly collaborative. It hamstrings your content by bundling it together with the structure and the formatting in a single document. I like Word, I think it’s a fine piece of software for everyday writing assignments, but it is not a suitable tool for modern technical communications. Surprisingly, despite the proliferation of tech comm tools and applications, it is still in common use in the industry it was my primary tool in my last job and it’s frequently listed in adverts for technical author jobs. My first few user documentation projects (before I started doing it full-time) were written in Microsoft Word. The fact of the matter is Microsoft Word is king and almost all offices have at least some version of the ubiquitous package installed on their workstations. You could also use Google Docs, but I’ve mentioned previously my scepticism about using open, cloud-based applications professionally (*cough* OpenSSL *cough* heart bleed). You could say WordPad is a word processor, but it is very limited and I seriously doubt anyone working in an office would use it professionally. Then there’s Kingsoft Writer, which is not too bad, but not in popular use. It’s still going today and is now developed by Corel. The older generation may mention Word Perfect, which was quite big in the 80s and 90s. OpenOffice Writer is the easy one and there is also its marginally superior, unofficial sibling, LibreOffice Writer. List five word processing applications that are not Microsoft Word. So which ones should an aspiring technical author or an author whose looking to move on in their career add to their repertoire? Word (Processors) The image at the top of the page shows the logos for many of the more popular tools and applications, but that’s not all of them by any means. Novice writers simply haven’t been in the industry long enough to build up any product knowledge, while experienced authors (especially those who have stayed in the same job for a long time) are probably using the same or similar tools to the ones they started out with. In fact there are so many different tools that perfecting any more than a handful of them is a challenge for all technical authors, both novice and experienced. It’s not surprising then that so many recruitment agencies list a daunting array desirable tools experience for technical communication jobs. Not only have the products been different at every company (from home computers and peripherals, to video game development tools, to payroll software and now television broadcasting equipment), the tools I have used to create my documentation have changed too. I have been a full-time technical author for 8 years and in that time I have worked for four different companies. ![]() Since there are 39 books in the Old Testament, it contains a tremendous amount of information. Old Testament Bible Trivia Questions and Answers One is never too young or old to play trivia games, and our collection should make any get-together, Bible class, or devotional more fun. We hope you have enjoyed our lists of Bible trivia questions and answers, as well as the Bible trivia quizzes.
Maybe if Krita’s developpers team was much bigger this kind of functionally will be implemented, but for what I currently see and understand, it’s a very small team, focused to try to fix bugs and improve existing functionalities.Īdding new functionalities take time, and then, there’s a choice to do, and the current choice is mainly to improve traditional painting tools. ![]() So, for me, without trying to code anything, I have so many question about how the functionality have to be implemented that’s already complex…Īnd maybe one would like to see the function implemented like this, and another one like that…
![]() It must not impose any bandwidth, phase, linearity or low level abnormalities which can be amplified by the following stage or stages. Audio NoteTM is unique in our facility to design, model, prototype and wind our own transformers in house, yet in spite of this it took even us six years to research and develop the necessary materials know how to achieve a musically transparent magnetic coupling from input to output in such a simple circuit.Įach transformer has to be complimentary in every aspect of behaviour to the one next in line. Our finding was that such a simple amplification circuit demands a degree of transformer quality never seen before in professional or domestic audio. However when we came to building a prototype we discovered why such nothing like it had been implemented before, and it was more than half a decade before we could bring the new Gaku-On to fruition. This topology reduces the number of passive parts in the signal path to just two resistors.ĭesigning the circuit was relatively easy on paper. In pursuit of ultimate simplicity, we decided that it would comprise just two active stages and three transformers one on the input, one as a driver and one on the output. Our ideas eventually led to a decision to develop a better sounding power amplifier circuit, a potential successor to the original parallel single-ended 211 based Gaku-On. Unsurprisingly, the more we explore, the more it becomes obvious that simplicity – and in particular keeping passive components completely out of the signal path or at least to an absolute minimum – is desirable for better and more faithful music reproduction. However, when it comes to executing this ideal, most of the rest of the industry has been wilfully forgetting this truth and has become addicted to complexity and technology as marketing statements, in stark contrast to this Audio NoteTM has continued to focus on studying and refining our understanding of how to achieve the above goal in order to create products that deliver better and more realistic music, lasting value and overall quality. ![]() The shortest signal path is generally the best, this is the professed aim of almost all the manufacturers of high quality amplification in the audio industry. I personally tested this option, it really works only that the ripping FPS is lower than the normal setting. Just check the “Safe mode” option on the main screen (above the “RUN” button). If technical problems happen during the encoding process or the ripping process is terminated unexpectedly, you can re-run the task in a safe mode. ![]() If your DVD movie has several titles, you can combine them in one video after conversion. The software also allows you to modify video tags in terms of genre, comments, name, and artist. You can pause playback, move a slider, and capture and save frames to PNG format. Without the built-in editing feature, you need to get an external video editor.Īnother good thing about the WinX DVD software is that it has a built-in media player, which allows you to preview your DVD clips. You can change the sample rate, frame rate, channel mode, rate, resolution, aspect ratio, codec, and bit rate of the video if you know it. Video and audio parameters can be modified to get your desired output. You can also restore the settings to default or apply them to all titles. It’s possible to adjust volume levels and expand or crop images. You can also specify its language and position or trim videos into smaller portions by marking the start and end times. You can also make a DVD backup by simply copying the full title or main title content or cloning the DVD to an ISO image or folder. It supports AVI, MPEG, MOV, MP4, WMV, AVC, Apple, Microsoft, Android, Sony, YouTube, Vimeo, and Facebook. The WinX DVD Ripping software supports a wide range of output profiles, from web video and general video to external devices. ![]() You just need to click on options to view the available preferences. It can rip the ISO images, rip VIDEO_TS folders or rip DVD discs. You’ll be provided with the usual options to make the start menu during installation. You also can use it for ripping the copy-protected DVDs which cannot be achieved by most free ripping tools.ĭownloading and installing the WinX DVD Ripping software won’t be a problem even for beginners. The following are some of the great features of this software. WinX DVD Ripper Platinum Review and Its Benefits Please do not download the cracked version of the software from unreliable sources as it’s not safe and possibly harmful to your computer.Ĭomplete guide: How to download, install and activate the WinX DVD Ripper Platinum? Well, WinX DVD Ripper is one of the software developed by Digiarty Software, which is a great multimedia software producer for the past 16-year.Īll the software by the company is safe to download and use if you download it from the official site. Since you can freely download the WinX DVD Ripper to trial it, people always ask: Is the WinX DVD ripper safe for use? Use coupon code: 22SUMWINX during checkout. Secret revealed: D o you really can get the WinX DVD ripping tool for Free? The answer is Yes but not now. ![]() It has a user-friendly interface and convenient options that simplify the entire process of converting DVD files into your desired format. The WinX DVD program also offers a basic video editor that lets you edit subtitles, trim footage, and crop videos. It provides high-quality results and allows you to rip raw DVD files like Video TS folders and disc images. It has customizable video and audio settings that allow you to tweak your conversions by adjusting the video’s technical aspects such as frame rate, aspect ratio, and bitrate before ripping it.Īs one of the top DVD ripping programs, it offers over 100 optimized conversion profiles, from common file formats to customized rips for gaming consoles, smartphones, and tablets. The WinX DVD Ripper Platinum Edition is a DVD ripping software that allows you to convert DVD movies into the most popular video formats and watch them on external devices or publish them online. Hurry up: On very rare occasions, WinX DVD Ripper Platinum is given out for free But NOW this full-features software is FREE for you to rip unlimited DVDs for 3-day – Click here to grab it. When you buy via links on our site, we may earn an affiliate commission at no extra cost to you. ![]() Organizational skills are one of your stronger assets. Remember to be specific about your desires. High levels of energy will determine your life. Yet most of the time you are very delicate and affectionate. Your seductive and magnetic powers give you some influence over other people. In that sense the life path of number eight is high as well as low. Thus you maintain a very ambivalent relationship with money. However being able to get money and managing it wisely are two very different things. Diarey meaning on a financial level Attracted by money you also know how to get it. Your weak points are: the nose, muscles, kidneys, genitals, lymph, immune system. Lively with high energy levels and a good ability to recover. The biggest weakness is your need to do too much and therefore constantly tapping into your energy reserves. What wellness means to Diarey? Figure of questioning and rebirth. Suitable occupations: finance, justice or law professions, building, the interior decoration, business, of sale or trade, activities linked to the army or the police, the middle of the sports, astrology, clairvoyance, numerology, psychology, all management, administrative or political positions and sometimes media. Good strategist who knows perfectly well what he is doing while mastering all sectors in which he is involved. Being passionate you need movement, never liking monotony. ![]() Always leading the ship with a good sense of appropriateness and repartee! Demanding to yourself but also with others you are honest and fair. ![]() Giving your body and soul to projects or activities that you love. Voluntary, purposeful, effective never fearing work overload. Diarey meaning related to work Fulfillment for this person depends on professional success. Being a whirlwind people can not help but notice you! Constantly questioning your beliefs is one of your strong points. Having an inner nature that incites taking advantage of the present moment and living life to the fullest can however sometimes make you pretty hard to live with, because of your self destructive behavior. Whole, stubborn, willful you are a fighter who can rise mountains with his determination. Attracting risk or adrenaline brings full control and makes you own your fate. You love explosive, incredible or unexpected situations, because they arise a thousand emotions inside. That is why you need to vibrate on a daily basis and always avoid lukewarm stuff! Full of passion and intuitive you are a real electric current. The name Diarey meaning and personality analysis. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |